Gene-Oriented Ortholog Database

Welcome to Gene-Oriented Ortholog Database (GOOD). This database is constructed and maintained by Transcriptome Discovery Lab (TDL), Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.

* What is GOOD?

Gene-Oriented Ortholog Database (GOOD) is constructed under consideration of the disturbance caused by multiple alternative splicing isoforms from a single gene locus ["Designating eukaryotic orthology via processed transcription units"]. GOOD provides a user-friendly web interface for researchers interested in comparing paired orthologous genomic loci in the transcriptional and functional aspects. Simultaneous presentation of two desired orthologous genomic loci allows researchers to rapidly identify differences in both alternative splicing events and gene functions between orthologs. GOOD v.1 contains orthology among four vertebrate species, namely, human, chimpanzee, mouse, and cow. Besides, GOOD takes in functional annotations from the Gene Ontology (GO) database and provides greatly improved graphical presentation of GO terms that promotes elucidation of functions’ hierarchical structure.

* How to use it?

There are two ways for users to access the GOOD website. One is to browse through a specific genomic locus. The browse page provides three steps for users to follow and then get into the choosed genomic locus. The other way is to search for a specific gene by its gene name, NCBI mRNA reference accession number or NCBI protein reference accession number through the search page. For academic use, users could further download flatfiles through the download page.

* How can I cite GOOD?

“Designating eukaryotic orthology via processed transcription units,” Meng-Ru Ho, Wen-Jung Jang, Chun-houh Chen, Lan-Yang Ch'ang, and Wen-chang Lin, Nucleic Acids Research, 2008 June; Volume 36: 3436–3442.

“Gene-Oriented Ortholog Database: a functional comparison platform for orthologous loci,” Meng-Ru Ho, Chun-houh Chen, and Wen-chang Lin, Database: The Journal of Biological Databases and Curation, 2010 February; Volume 2010, baq002.